High Precision Measurement of Neutrino
Oscillation at Daya Bay
Project Coordinator: Prof Ming Chung Chu
(CUHK)
The recent discovery of neutrino oscillation -a neutrino travelling in space transforms from one type to another - has profound impacts on particle physics, astrophysics and cosmology. The Daya Bay Reactor Neutrino Oscillation Experiment aims to measure a key but yet unknown neutrino oscillation parameter, θ13, to an unprecedented precision of better than 3 degrees, which is critical to the design of future experimental tests of a possible explanation of why matter dominates anti-matter in the universe, a key condition for our existence.
The Hong Kong team has been an active member
of the Daya Bay Collaboration, an international
team with 38 institutions. We will contribute
to the commissioning and monitoring of the
experiment and analysis of data, with the
help of a subsystem of the antineutrino
detector built by our team. We will also
design and construct a continuous radon
monitoring system as well as a cover gas
system to minimize radon contamination of
the detectors.
Schematic Identification of Predictors
of Treatment Non-Responders in Patients
with Systolic Heart Failure
Project Coordinator: Prof Cheuk Man Yu (CUHK)
Chronic heart failure (CHF) is a major
public health problem in Hong Kong. Data
from our heart failure registry shows that
1-year mortality and readmission for heart
failure (HF) is about 50%. Over the past
two decades there have been significant
advances in the treatment of systolic heart
failure with the use of drugs that block
the major neurohormonal responses to the
initial injury. Recently cardiac devices
such as biventricular pacing (or CRT) which
rectify the abnormal conduction and contraction
in CHF have also been used for CHF treatment.
Although large scale clinical trials have
demonstrated the efficacy and safety of
the commonly used drugs for CHF, it is a
common clinical observation that not all
patients respond as well as others and some
not at all. Our hypothesis is in that myocardial
fibrosis and inflammation are key mediators
of non-response to CHF treatment. We wish
to undertake a large scale project to attempt
to estimate the prevalence of non-response
and how can we identify these patients.
We will combine the use of advanced echocardiographic
imaging techniques and novel biochemical
and molecular (microRNAs) biomarkers to
establish and validate an Assessment Model
which identify treatment non-responders.
Cardiac MRI will also be performed in a
subgroup to determine the relationship between
cardiac scar burden and echocardiographic
function. The project also has the potential
of identifying new diagnostic and prognostic
markers for CHF (biomarkers and microRNA),
pioneer new approaches to manage CHF, as
well as geared towards the development of
new treatment targets.
Identification of Redox-sensitive
Proteins and Characterization of Their Functions
in Regulating the Oxidative Stress Response
in Arabidopsis
Project Coordinator: Dr Yiji Xia (HKBU)
Cellular redox status regulates a variety of biological pathways. Oxidative stress is linked to various human diseases. Similarly, cellular redox homeostasis is a common mediator of physiological responses to environmental stresses in plants. Oxidative stress signals are sensed by redox-sensitive proteins which then transduce the signals into physiological responses. We will develop redox proteomics approaches to identify redox-sensitive proteins in the model plant Arabidopsis and investigate their functions in regulating physiological responses to oxidative stress conditions. The knowledge from the study will be greatly helpful in improving crop productivity. The redox proteomics technology platform developed from the proposed research can also be applied to similar studies in other organisms including humans.
Mass spectrometry-based metabolomics
for the characterization of cellular metabolic
pathways associated with the development
of hepatocellular carcinoma
Project Coordinator: Prof Zongwei Cai (HKBU)
We will develop and apply mass spectrometry (MS)-based metabolomics for investigating hepatocellular carcinoma (HCC) that is one of the common diseases posing major threat on human health in Hong Kong. Systems-level metabolic profiling of different cell lines will be analyzed for deciphering the functions of eIF-5A2 and PDSS2. Furthermore, cancer stem cells (CSCs) will also be investigated by metabolomic approach. The use of CSCs marked by CD133 surface phenotype and bearing features would provide new insight for metabolic programming associated with HCC development. The differentiating metabolites will be highlighted and identified to localize the metabolic pathways associated with HCC development by using non-targeted and targeted metabolomic approaches. For the validation, analytical techniques will be applied for the determination of enzymatic mutations or abnormally enzymatic activities in cancer cell lines. The metabolic networks will be simulated for opening a novel systemic insight into the development of HCC.
Development of efficient luminogenic
materials in the aggregate state: fundamental
understanding and practical applications
Project Coordinator: Prof Ben Zhong Tang
(HKUST)
The development of new light-emitting materials has allowed us to gain new knowledge of the world around us by opening a new avenue to scientific achievement and societal development. Thanks to the enthusiastic efforts of scientists, a large number of luminescent molecules have been prepared. These materials emit intense light in solutions but they emit weakly or even not at all in the solid state. This problem must be solved because for most real-world applications, luminescent materials are used as solid films. In this project, we discovered the phenomenon of aggregation-induced emission in some molecules. These materials show stronger emissions in the solid state than in solutions. We identified its cause, based on which, we prepared diverse materials, ranging from small molecules, to organometallic complexes, to high-molecular weight polymers. We explored their high-technological applications as fluorescent chemosensors for as example explosives, as biological probes for imaging, diagnosis and therapy, and as solid-state emitters for organic light-emitting diodes.
Protein-phosphoinositides Interactions
in Neuronal Signaling
Project Coordinator: Prof Mingjie Zhang
(HKUST)
Phosphoinositides (PIPs) are important signaling lipids that are distributed in various cellular membranes. PIPs, via binding to proteins, actively regulate numerous cellular processes. In this project, we will continue to investigate the structures and functions of a series of protein-lipid interactions that are implicated in both normal functions as well as the etiology of brain and heart muscle cells. We aim to elucidate the biochemical and structural basis of the interactions between PIPs and these proteins and to uncover the physiological significance of these newly identified protein-lipid interactions. The outcome of this project is expected to make important contributions in understanding a number of human diseases including neurodegenerative diseases and cancers.
Programming the Second Generation
Tumor-targeting Bacteria
Project Coordinator: Dr Jiandong Huang (HKU)
Cancer remains a leading cause of death with current therapeutic methods. Novel therapies are therefore in urgent needs. One potential method is to use bacteria as cancer therapeutic agent. Since bacteria can sense their environment, distinguish between cell types, synthesize and deliver drugs into cancer cells, attempts are made to program bacteria to attack tumors. Current advances in synthetic biology technology offer great opportunities in refining this approach. In this project, we will establish a stepwise approach to program bacterial strains that are able to detect tumor microenvironment, effective in killing cancer cells and safe to normal tissues, so that they can ultimately be used clinically to treat cancer patients.
A Multi-disciplinary Approach to
Investigate Vascular Dysfunction in Obesity
and Diabetes: From Molecular Mechanism to
Therapeutic Intervention
Project Coordinator: Dr Aimin Xu (HKU)
Cardiovascular disease (CVD), including
stroke, heart attack and periphery artery
disease, is the major cause of death and
hospitalization in the ageing population
worldwide. Much of the high incidence of
CVD is attributed to the epidemic of obesity
and diabetes. Unfortunately, none of the
current therapies can reverse the progression
of CVD. To develop more effective medications,
it is of great importance to understand
the pathological pathways that link obesity,
diabetes and vascular disease. With the
support from our previous RGC Collaborative
Research Fund (CRF), we have identified
three fat-derived circulating factors as
a key mediator of obesity-related CVD in
mice. The objective of this collaborative
project is to comprehensively investigate
the pathological roles and clinical relevance
of these circulating factors in the development
of CVD in both large animals and humans.
The results will help us to develop new
diagnostic tools and better therapeutics
for risk prediction and prevention of CVD.
Self-Assembled Synthetic Ion Channels:
Design, Characterization and Biomedical
Applications
Project Coordinator: Prof Dan Yang (HKU)
Ion transport across membranes in cells
is controlled by ion channel proteins. Dysfunction
of ion channels has been associated with
many severe human diseases such as cystic
fibrosis, asthma, hypertension, epilepsy
and myocardial infarction. Therefore, developing
drugs that modulate the functions of ion
channels or regulate ion transport have
received significant attentions in pharmaceutical
industry.
In our previous research work supported
by RGC Competitive Earmarked Research Grants
(CERG) (HKU7367/03M) and RGC Collaborative
Research Fund (CRF) (HKU 2/06C), we have
discovered a novel class of small molecules
that self-assemble in the lipid membranes
of living cells into synthetic chloride
channels, which increase chloride conductance
in human epithelial cells, modulate membrane
potentials, and even can initiate relaxation
of smooth muscles.
In this proposed research, we plan to continue
our inter-disciplinary collaborations by
combining the expertise in chemistry, physiology,
cardiology and pharmacology to discover
synthetic ion channels that selectively
transport small anions or cations across
biological membranes and explore their potential
biomedical applications in the treatment
of human diseases associated with channel
dysfunction, such as cystic fibrosis, asthma,
hypertension, and myocardial infarction.
Smart Grid
Project Coordinator: Prof Victor On Kwok
Li (HKU)
Concerns with global warming prompted governments throughout the world to pursue policies aiming at increasing renewable energy generation so as to reduce greenhouse gases due to electricity generation with fossil fuels. However, due to the intermittent characteristics of renewable energy sources such as wind and solar, it is a challenge for a system with large renewable generation capacities to implement real-time power balance. Recently, many countries have announced smart grid research programs to re-vitalize their electricity generation and distribution infrastructures using modern technologies such as communication network, sensor network, power electronics, and control technologies to manage the power grid more effectively, and to cope with such complexities as fluctuating energy sources and consumption. The key objective of this proposed project is the integration of information technologies and electric energy generation and distribution technologies to design innovative means to manage and control the electricity generation and distribution network. A novel hybrid simulation laboratory will be built to test our research results in innovative designs for efficient communication, computing and control of smart grids.